• Pain in areas of bone involved by tumor and that does not respond to hormonal therapy is best treated by
  external beam radiation to the area of pain. Relief is often felt within days.
• Observation without further immediate treatment may be suitable for selected patients who have no
  symptoms.
• External beam irradiation for possible cure in highly selected Stage D-1 patients, since patients with this
  limited Stage D disease will occasionally respond to external beam radiation to the prostate and pelvic area.
  Cure is rare.

Five-Year Survival  55 percent for D-0, 40 percent for D-1, 35 percent for D-2 and D-3

Investigational 
• Combination hormonal manipulation with LH-RH agonists and progestational agents.
• Chemotherapy protocols. 
• Alternative forms of radiotherapy with neutron beams. New devices producing more powerful forms of
  external radiation using proton and neutron beams have been developed, and patients are being treated in
  clinical trials .